Brazilian mushroom (Agaricus blazei Murill), also known as Agaricus blazei, mushroom, sunlight mushroom,  taxonomic classification belongs to the genus Basidiomycetes mushroom mushroom mushroom [1 ].

The fruit body of the Brazilian mushroom contains 89-91% of water, and the total dry matter contains about 48% and 18% of protein and carbohydrate respectively, and the lipid content is only 0.5%. In addition, it contains large amounts of minerals (such as potassium, phosphorus, etc.). Calcium, Magnesium, and Zinc [2, 3].

Brazilian mushrooms contain a variety of biologically active substances such as β-1,3-D-glucan, β-1,4-D-glucan, β-1,6-D-glucan and proteoglycans [4 ]. In vitro and animal experiments suggest that Brazilian mushrooms have a certain degree of immunomodulatory effect.

The study found that the Brazilian mushroom extract can promote the secretion of TNF-α, IL-1, IL-8, and NO by murine bone marrow macrophages or human monocytes [5-7], and promote the activity of spleen NK cells in BALB/c mice. Production of antigen-specific CD8+ cells and INF-γ [8-12], activation of the human complement system through alternative pathways [13], accelerated maturation of bone marrow-derived dendritic cells and production of IL-12 [14, 15 ], Induce the production of mouse antibodies, MAC-1 +, and CD25 + cell populations [16, 17] and increase the number of CD4 + cells and CD8 + cells in the mouse spleen [18].