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On Brazilian Mushrooms from the Perspective of Empirical Medicine

《Brazilian mushroom introduction》:

Brazilian mushroom (agaricus blazei murill) belongs to the genus Basidiomycetes, originally originating in Brazil, Peru, and other places in South America, and was first discovered in the area of Pieda in the suburbs of Sao Paulo, Brazil. The Japanese call it Agaricus blazei. Due to the extremely special environmental conditions required for the growth of Brazilian mushrooms, the daytime temperature needs to reach 35°C, the temperature difference between day and night needs to be above 10°C, and the special culture soil makes the Brazilian mushrooms extremely rare. The annual collection of the mushrooms in the country of origin is only 10 tons. , it is quite expensive. Since ancient times, Brazilian mushrooms have become daily foods for local people in Piedecai. In the 1960s, the results of the immunological investigation of Dr. Sinden from the University of Pennsylvania and Dr. Lambert from the Lambt Institute revealed the Piedecati region. The secret to longevity and health. Since then, Brazilian mushrooms have become famous overnight. Research on Brazilian mushrooms by the medical community and the academic community has also been published. In the United States and Japan, a wave of Brazilian mushroom health care was aroused. In recent years, it has become the first place in the sales of Japanese herbal medicine health products ( Japan produces about 100-300 tons per year, and about 300,000 to 500,000 people are health foods.

    《Brazilian mushroom features》:

Each acarid contains more or less polysaccharides, and its species and structure are also different. The particular ingredient of the Brazilian mushroom is that it contains a unique and rich Brazilian mushroom polysaccharide. Its composition has been studied and found to include at least α-d-glucan, β-d-glucan, β-galactose, and dextran. Sugars, β-(1-6)-d-glucan protein complexes, xyloglucans, and other polysaccharides with different molecular structures have molecular weights above 10,000 dalton, and in general, the molecular weight of polysaccharides. To be effective above 6,000 dalton. Studies have shown that high-molecular polysaccharides can induce many physiological reactions and may regulate physiological functions.
In addition, Brazilian mushrooms are richer in protein, lipids, minerals, vitamins, and dietary fibers than other acarids. Lipids are rich in linoleic acid-based unsaturated fatty acids.

    《The Practical Medicine of Brazilian Mushroom》:

According to the principle of empirical medicine, we entered the pub med search page of the National Library of Medicine in the United States with agaricus blazei murill (abm) as the key word. A total of 29 English articles were found. During the period from 1994 to 2006, most of the documents were research results of in vitro experiments or animal experiments. The contents of the report can be summarized mainly to confirm that the residents of the Papiledad region have long been known for their longevity and cancer. The low incidence of infections and chronic diseases may be related to the consumption of Brazilian mushrooms. Therefore, it can be seen that the results of the Brazilian mushroom extract can enhance killer cell function, activate apoptosis programs, strengthen antibody production, enhance immunity, inhibit tumor angiogenesis, activate complement, and enhance dendritic cell maturation, etc. Growth or transfer of machines. In addition, there are also anti-diabetic drugs that can be used to increase the antibody titer of vaccine injections. In vitro sterilization and fungicidal effects can be seen, and the body can strengthen the effect of fighting infections.

Unfortunately, unlike other anti-cancer drug studies, we cannot identify the rigorous Phase I, II, and III human clinical trial reports, the only one of which is the double-blind trial published by a medical center in Korea. The subjects were mainly women with gynecological cancer (including cervical cancer, ovarian cancer, and endometrial cancer). They received extracts of Brazil mushroom or placebo during chemotherapy, and then they were tested for blood related immunity by blood test. Changes in the number of cells and the use of questionnaires to assess their quality of life related items. The test results show that the use of the extract will increase the activity of the natural killer cells, and the side effects of chemotherapy such as insomnia, hair loss, loss of appetite, vomiting, and poor stamina can be alleviated. Basically for the general public, if we only emphasize the above test results, I believe we can persuade everyone to accept it. However, since we think it is a scientific research report, we should use a scientific point of view to make an objective and objective review to facilitate your reference.

There are basically a few obvious deficiencies in the study itself. This is also something we should be careful when we want to quote for reference. A total of 100 subjects participated in the trial, although randomly assigned, 39 for abm and 61 for placebo. The distribution of the two groups of cancers, phases, and chemotherapeutic agents used was not Similar to the two groups, the use of abm drugs is based on three doses of one pack per day as the therapeutic dose, and there is no animal trial or clinical trial to adjust the dose according to the basic requirements of weight. There are many differences in the analysis of immune cells, but these are only detailed in the full text. In the study of cancer treatment, the survival rate, survival, chemotherapy response rate, and standard chemotherapy side effects that everyone valued most were not touched. Instead, only the subjective feelings of the subjects were used as questionnaires to investigate, and there was suspicion of avoiding weight. The most important thing was to carry out this research directly without the support of the research evidence of the first phase and the second phase of the clinical trial, although the abm was attributed to Health foods, but also cause people to worry about whether their ethical considerations are rigorous, because the text does not indicate that the study had been approved by the hospital ethics committee. In addition, media reports recently pointed out that the Brazilian mushroom extract produced by a Japanese pharmaceutical factory is contaminated due to its tendency to absorb heavy metals when it grows. Consumers must also pay attention to the heavy metal content when selecting Brazilian mushroom products.

In summary, if abm is used as food, its controversy may not be high, but if it is to be treated as the main force for curing cancer, or to publicize its efficacy, its legitimacy and scientificity should be insufficient. Therefore, we would suggest that the general public should have more careful consideration when investing in these healthy foods and should not cast too much expectation. Because it still has many problems in its use for clinical applications, it should not stop regular medical treatment, and it should not cause household economic pressure. We are even more hopeful that when major pharmaceutical companies can sell these products, they can also use these current scientific and scientific research methods to clarify many unclear problems, so that clinical staff can apply scientifically. That is the people. The blessing of the sick.